If your "app" is written in Javascript and excludes many potential users without a technical advantage, you could save a lot of maintenance time and cost by just writing it as a native desktop application instead.
Yup: It is much more flexible because it has full access to the operating system, you won't have to work around the limitations of a web browser, it will require no fast internet connection (but it could perfectly work with one) while hogging less RAM and blind/disabled people are able to use it.
What else?
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If your "app" is written in Javascript and excludes many potential users without a technical advantage, you could save a lot of maintenance time and cost by just writing it as a native desktop application instead.
But that's a totally different thing.
Yup: It is much more flexible because it has full access to the operating system, you won't have to work around the limitations of a web browser, it will require no fast internet connection (but it could perfectly work with one) while hogging less RAM and blind/disabled people are able to use it.
What else?