Yes, you should always use a real email address that belongs to someone. If you're not up to answer the replies, that's your decision unfortunately but you should be aware of the consequences. ISPs will penalize you.
Some people skip over the unsubscribe link and hit reply directly asking to be removed, no-reply is a terrible idea because it stops you building a relationship with a customer. Even if they just want to unsubscribe, you could answer back with some questions regarding why they want to unsub. Always extra stuff that is good for product management ;)
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