"usecols" should help, use range of columns (as per excel worksheet, A,B...etc.) below are the examples

1. Selected Columns

df = pd.read_excel(file_location,sheet_name='Sheet1', usecols="A,C,F")

2. Range of Columns and selected column

df = pd.read_excel(file_location,sheet_name='Sheet1', usecols="A:F,H")

3. Multiple Ranges

df = pd.read_excel(file_location,sheet_name='Sheet1', usecols="A:F,H,J:N")

4. Range of columns

df = pd.read_excel(file_location,sheet_name='Sheet1', usecols="A:N")