Screen or tmux is very helpful tool if you use either some text-based tool (like e.g. text-based mail reader like alpine or mutt), or use an interactive session like e.g. ipython, and you are on not entirely reliable SSH connection. Loosing email you have been composing for 15 minutes because network connection dropped is... irritating...
For example screen -S alpine -d -RR alpine reconnect to session (forcefully closing it if it did not timed out yet), or start alpine from start if there is no screen session to go back to - for example if the host was rebooted.
screen -S alpine -d -RR alpine
The nohup command is better for batch jobs, like large wget / curl download.
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