Development and also approval regarding ferroptosis-related lncRNAs personal pertaining to hepatocellular carcinoma.

BACKGROUND Nosocomial infection (NI) increased the rate of mortality, morbidity and financial load for patients and Healthcare Facilities (HFs). Regarding to many advances in controlling NIs, it is still a worldwide problem. Layout of HF (department configuration) has a vital role in controlling NIs, because the pathogen microorganisms can transmit among departments. Some departments can transmit microorganisms much more than the other departments, called cause, and some of them received the microorganisms more than the others, called effect. Both are risky. selleckchem OBJECTIVE This study attempts to propose a comprehensive algorithm for selecting low risky department(s) for upgrading of HFs by use of Multiple Criteria Decision-Making (MCDM) methods. METHODOLOGY Among MCDM methods, this study has hybrid WSM and Expanded DEMATEL, beside modified Nominal Group Technique to minimize NIs risk in upgrading of HFs. The resulted decision-making algorithm is validated by implementing in a HF as a case study. RESULTS The final proposed algorithm and the resulted low risky departments are approved by head and manager of the HF. Therefore, the algorithm is valid, and the feasibility of algorithm is approved by achieving the result from implementing of algorithm in the case study. CONCLUSION To conclude, the proposed algorithm can be a solution to minimize the risks of NIs, while upgrading, in each HFs and make the decision of HF's managers easier and logic. BACKGROUND AND OBJECTIVES Middle East Respiratory Syndrome Corona Virus (MERS-CoV) outbreak in 2014 was associated with high public anxiety in the affected countries. Media speculations may have increased this psychological distress. The healthcare community was the most distressed because they were at the highest risk of infection. This study is the first to explore MERS-CoV epidemic impact on medical students' perception and determinants of their psychological distress during this outbreak. METHODS We randomly selected and surveyed 200 students from the College of Medicine at King Saud University, Riyadh, Saudi Arabia. A predesigned questionnaire was answered by participants, and the collected data were statistically analyzed. RESULTS One hundred and seventy-four (87%) responded. Female students had a significantly higher mean stress level than males (P 14). The stress level (as reported on 1-10 scale) shows significant correlation with Generalized Anxiety Disorder (GAD-7) score. We found in this study that significant predictors in our model, in terms of more significant to the least, were an increased self-report on hygienic habits, self-reported social avoidance, the generalized anxiety score and finally being female gander while other variables including numbers of resources access, agreeing with public fear and knowledge score on MERS-CoV all were found to be non-significant. However, the number of accessed resources, as per students, has borderline significant correlation with higher self-reported anxiety from MERS-CoV. CONCLUSIONS Medical students' psychological needs during the MERS-CoV outbreak should be addressed appropriately. Our results highlight the need to establish psychological support programs for medical students during an infectious disease outbreak. BACKGROUND The amygdala can enhance emotional memory encoding as well as anxiogenesis via corticotropin-releasing factor neurons. However, the amygdala's explicit role in emotional encoding remains unclarified in humans. We examined how functional connectivity (FC) of amygdala subnuclei affects emotional encoding, considering its mechanism in which anxiety, attention, and cortisol conceivably participate. METHODS A total of 65 healthy humans underwent resting-state functional magnetic resonance imaging scans and saliva collection at 10 points in time over 2 days. FC analysis was performed for basolateral amygdala subnucleus (BLA) and centromedial amygdala subnucleus. We assessed attentional control via an emotional Stroop task and assessed emotional encoding via a facial identification task that examines how strongly a neutral face is memorized when accompanied by an emotional face (fearful, sad, or happy). FC and task performance were compared between high-anxious and non-high-anxious groups classified by anxious personality scores. RESULTS BLA connected with subgenual anterior cingulate cortex (sgACC) in proportion to the strength of fear-related encoding, whereas centromedial subnucleus connected with caudate nucleus for happy-related encoding. The high-anxious group showed more enhanced fear-related encoding but impaired happy-related encoding compared with the non-high-anxious group. BLA-sgACC FC was more intensified in the high-anxious group than in the non-high-anxious group; however, centromedial-caudate FC did not differ between them. Although emotional encoding was uncorrelated with either attentional control or cortisol, BLA-sgACC was positively correlated with cortisol increase after awakening. CONCLUSIONS The study revealed that neural interactions of BLA, specifically with sgACC, might play a critical role in fear-related memory encoding, depending on the individual's level of anxiety. These findings aid in understanding the complicated mechanisms of emotional memory in anxiety disorders. BACKGROUND Traumatic orthopaedic injuries are responsible for 5.8 million deaths every year, with 90% occurring in low to middle income countries. Nursing is an under-utilised resource in global trauma care and little research exists into the availability or training of skilled orthopaedic nurses in low to middle income countries. OBJECTIVES This scoping review aimed to summarise and critique the existing body of research to identify if the development and, in some cases establishment, of trauma and orthopaedic nursing should be a priority in low resource settings. The review also aimed to identify any barriers to the advancement of the speciality, and any existing solutions to support nurses' training and development. METHODOLOGY A scoping literature search was conducted, searching four databases (ProQuest, Medline, CINHAL and SOLAR) with key words and phrases to identify current literature. RESULTS Eleven papers were identified. Key themes included the need to upskill and utilise the existing nursing workforce to provide care to trauma patients.selleckchem