For my laptop: I clean off the keyboard with an alcohol handwipe and wipe the screen with a microfiber cloth every few months.
For my desktop: I just wipe off the monitor with my shirt when it looks dusty. I've cleaned the keyboard three times in the 5 years I've had it, about time to do it again. And that cleaning includes removing all the key caps (gaming keyboard) and washing them in a bowl with water and soap, and using compressed air to get rid of all the crap under the keys.
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