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Paul Franco
Paul Franco

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PPARγ2 features as being a cancer suppressor inside a translational mouse button style of human being cancer of prostate.

The dark-field image (DFI) in a grating interferometer involves the small-angle scattering properties of a material. The microstructure of the material can be characterized by an analysis of the auto-correlation length and the DFI. The feasibility of a DFI in a laboratory x-ray source with grating interferometry has been reported, but a follow-up study is needed. In this study, the random stress distribution was measured in the laboratory environment as an applied study. SiO2 mono-spheres as a cohesive powder with a 0.5 µm particle size were used as the sample. The microstructural changes according to the stresses on the particles were observed by acquiring a DFI along the auto-correlation length. In x-rays, a random two-phase media model was first used to analyze the characteristics of cohesive powder. This study showed that the microstructure of materials and x-ray images could be analyzed in a laboratory environment.Semiconductor-based heaters for diamond anvil cells (DACs) have advantages over metal wire heaters in terms of repeated use and the ability to reach higher temperatures. We introduce a cylindrical SiC heater for an externally heated DAC (EHDAC) that works satisfactorily at temperatures up to 1500 K and pressures around 90 GPa. The heater is reusable and inexpensive, and only slight modifications to the DAC are required to fit the heater. Experiments on melting of NaCl and gold are conducted at ambient pressure to test the temperature accuracy of the EHDAC system, and resistance measurements on iodine at high pressures and temperatures are performed to assess the heater assembly. These test runs show that a uniform and accurate temperature can be maintained by the EHDAC assembly, which has potential applications to a variety of transport property measurements.We report on the optimization of a BremsStrahlung Cannon (BSC) design for the investigation of laser-driven fast electron populations in a shock ignition relevant experimental campaign at the Laser Megajoule-PETawatt Aquitaine Laser facility. In this regime with laser intensities of 1015 W/cm2-1016 W/cm2, fast electrons with energies ≤100 keV are expected to be generated through Stimulated Raman Scattering (SRS) and Two Plasmon Decay (TPD) instabilities. The main purpose of the BSC in our experiment is to identify the contribution to x-ray emission from bremsstrahlung of fast electrons originating from SRS and TPD, with expected temperatures of 40 keV and 95 keV, respectively. Data analysis and reconstruction of the distributions of x-ray photons incident on the BSC are described.Intravascular ultrasound (IVUS) has become a useful tool in the detection of coronary artery disease. However, non-uniform rotation distortion (NURD) reduces the image quality. In order to suppress the influence of NURD, a piezoelectric motor that can meet the requirements of IVUS catheters has been proposed. The motor has a diameter of 1 mm and a length of 10 mm using the new polarization direction proposed in the paper. A 45° mirror is fixed on the top of the motor to reflect the ultrasound transmitted from the transducer. The manufacture and drive of the piezoelectric motor is simple, and the maximum speed of the piezoelectric motor can reach 6450 rpm under the voltage of 20Vp-p. The minimum power required by the rotating motor is only 0.038 W, which can be directly driven by the signal generator without a power amplifier. The motor can operate at a low voltage and still has a high and stable speed. Meanwhile, the speed of the motor is controllable and has a satisfactory stability with a maximum angular error of 8°. The images detected by the cooperation of the motor and the ultrasonic transducer are also shown, which indicates that the motor has the rotational stability that meets the imaging requirements and the potential for application in the IVUS catheter to help improve the image quality of the coronary arteries and prevent and help treat potential diseases.A technique for more accurately modeling and improving the spatial resolution of heavy ion beam probe measurements is described. We use a set of particle trajectories to numerically determine the focusing properties of a complicated three-dimensional magnetic field and characterize these properties with a transfer matrix. We then modify the transfer matrix approach of traditional ion optics to include a parameter that describes the ionization location of the detected ions. The ion optics model calculated using this technique enables a more accurate description of the particle trajectories than previously feasible. The model also allows one to easily determine an initial beam focus that could be used during experimental operation to optimize the spatial resolution of measurements. The technique has been applied to the design of a heavy ion beam probe diagnostic for the Wendelstein 7-X stellarator, and improvements in the modeled spatial resolution by a factor of about 2 over previous estimates are possible. The improved spatial resolution will enable measurements of plasma fluctuations with smaller wavelengths than would otherwise be possible.Solenoids are frequently used for focusing low-energy beams. In this paper, we show how they can serve as multipurpose diagnostics tools to measure various beam parameters, including energy, emittance, the second moments of the transverse distribution, and the beam position and angle with respect to the solenoid's axis. The energy measurement is based on rotation of the plane of the transverse motion, as opposed to generating dispersion with a dipole. Measurement of the beam trajectory with respect to the solenoid axis is done by analyzing the beam orbit downstream of the solenoid while varying its current. The second moments are calculated by analyzing the beam image on a profile monitor while accounting for the beam rotation caused by the solenoid. selleck kinase inhibitor We describe in detail the corresponding procedures and the experimental results of these measurements.Resonant-type piezoelectric impact motors can improve the output capability effectively. A new construction of asymmetric inertial masses is proposed to synthesize approximate saw-tooth wave resonant vibration with matched anti-phase and in-phase modes. A prototype is designed, manufactured, and tested. With 40 Vp-p, 400 Hz exciting voltage for the anti-phase mode and 16 Vp-p, 800 Hz exciting voltage for the in-phase mode, the prototype provides a maximum no-load velocity of 17.2 mm/s and a maximum output power of 0.72 mW with 100 mN load. The velocity and output power of the prototype in the proposed resonant state are near three orders of magnitude higher than those in the traditional quasi-static state.selleck kinase inhibitor

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