Pomodoro timer. I too work from home a lot and I find taking a break regularly and getting some movement in helps me. Often times on lunch I use some free weights, or I do something cardio friendly to get my blood moving. This is something I was never able to do at the office. Also, I really enjoy taking a stroll around my neighborhood weather permitting.
I think the most important thing for me is to get away from the computer for a few minutes periodically.
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