All major browsers support the required specs for web components since late last year, except Edge (Chromium Edge should fix that).
I've been building framework-less on Stencil for almost a year now and I have to say... It's AMAZING. I honestly believe web components are what the frameworks have been trying to give us for the last decade.
Now that they are part of the spec and relatively stable, I don't really see the point in the Frameworks anymore, other than to provide an opinionated standard, and access to all the libraries built to support them that don't work outside of their context.
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