I'm with Thomas here. E-mail often gets abused for other purposes, none of which it's very good for (I blame MIME types for most of this scope creep!). I would prefer to use the right tools (typically a tracking tool, a pub/sub information platform, and human interaction), then drop both e-mail and instant messaging completely due to the amount of distraction caused by them. Inbox Zero is a coping strategy to a bigger problem of unplanned communication...
A particular pain point I find with e-mail is that the source routed nature of addressing causes all manner of communication gaps, some malevolently used by manipulators to introduce or cut people out of conversations, more typically a lack of information on who should be part of something and no guidelines or training on using it well (IMO another coping strategy for a poor choice of tool).
OK, I feel better now :)
[edited to add this search link - this topic has been here a few times]
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