I just started using it for a new project that is rather large. I've been a big tachyons fan for years but I felt I needed tailwind this time around because it allows for more fine tuned configuration options as well as some additional breakpoints. That being said, it is a lot heavier than tachyons so I added purgecss to the project, which, while not hard was some added complexity so as not to serve the entire library all the time. I also generally found the class names of tachyons a bit easier to memorize (that may just take more time also there are lot less to remember). Overall I definitely will be using tailwind a ton in the future but still keep tachyons in my back pocket for smaller projects where the restrictions of less allow me to develop faster.
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