You can certainly have clients as friends and friends as clients as long as there's a clear understanding of the line between business and friendship. I've worked with some friends without issue and I've also lost friends over bad business arrangements.
I'm at a point in my career now where I would rather refer a friend to a colleague instead of work with them directly, but I know other freelancers who have no problem at all working with friends as clients (or clients as friends).
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