Discussion on: How do you deal with the endless stream of interruptions that we have nowadays?

I turn off PC notifications, then I check slack periodically when I feel like (I've 3 monitors and the slack is always opened on a part of one).
Educate people to use ticket service instead rushing into IT department which is a bad practice unless something is burning.

Also earbuds with Spotify or Youtube are a must. if you want to say me something use slack, hangouts, come here and let's talk, this avoids people from shouting from side to side of the department disturbing others.

Of course it's nice to keep conversations with our colleagues while at work and the concentration needs are less than average, not having human contact causes depression so don't forget that.