As long as you're not trying to go strictly mobile devices (phone, notepad, etc), probably fine. While I like my wife's Surface, its keyboard is really only suitable for very light content-creation. If you're doing more than just surfing, you really need an actual keyboard - even a laptop's.
I use a laptop because, when I work from home, I work from my couch. If I had a desk at home, I might still use a desktop. That said, last time I had a desk and destkop system at home, I always just XDM'ed into it from my laptop while sitting 10' away on my couch. Couch-computing is hard to beat.
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