I agree with Ali, it depends entirely on what you want to build really and in terms of career it's best to look what is currently around you. For example, I live in South Wales, UK in a small place called Swansea with currently hardly any tech companies around. The ones that are around use React so it's wise for myself to learn React but understanding the fundamentals of plain vanilla JavaScript is also extremely important.
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I agree with Ali, it depends entirely on what you want to build really and in terms of career it's best to look what is currently around you. For example, I live in South Wales, UK in a small place called Swansea with currently hardly any tech companies around. The ones that are around use React so it's wise for myself to learn React but understanding the fundamentals of plain vanilla JavaScript is also extremely important.